She was forced to end her career as a volleyball player due to a knee injury. After this, DeBuono started her acting career, and she performed in a stage play directed by a former student, Ashley Judd. She studied at the American Academy of Dramatic Arts and graduated in 1994. In 2003 she earned a master degree in clinical psychology.
She appeared in the last three seasons of Star Trek: Deep Space Nine as M'Pella. She has worked as a stand-in, photo double, and body double for Terry Farrell. DeBuono received no on-screen credits until her final appearance in the episode The Dogs of War. DeBuono also appeared as a background regular in several episodes of the television series Chicago Hope as a paramedic. DeBuono was involved in the comedy series Jenny, The Pretender, Pacific Blue, Martial Law, Becker and Exes and Oh's.
She has also appeared in a few films, including the short project Gay Propaganda (2002) and the award-winning Out at the Wedding (2007), the romantic comedy And Then Came Lola (2008), and the short drama Tremble & Spark (2008). For the short film The Touch, by Jane Clark, she worked as associate producer and still photographer.
From Wikipedia, the free encyclopedia