Scorsese first began her career as a model. Her first television role was in the action series The A-Team in 1985. Her feature film debut came the following year in the B-movie horror thriller Velvet Dreams - When Dreams Turn Deadly. Her best-known role was in the 1989 Christmas classic National Lampoon's Christmas Vacation as lingerie saleswoman Mary.
In the 1990s, she appeared in a number of episodic roles, including New York Cops - NYPD Blue and Emergency Room. She also had a small role in Jennifer Chambers Lynch's thriller Boxing Helena alongside Julian Sands, Bill Paxton and Art Garfunkel.
She is not related to Martin Scorsese.