In 2020, he co-created and began starring as the lead in the Apple TV sports comedy series Ted Lasso, which earned him four nominations at the Primetime Emmy Awards, including wins for Outstanding Comedy Series and Outstanding Lead Actor in a Comedy Series, two wins for the Golden Globe Award for Best Actor in a TV Comedy Series in 2021 and 2022 and for the Screen Actors Guild Award for Outstanding Actor in a Comedy Series. Sudeikis has also acted in recurring roles in the comedy series 30 Rock (2007–2010), It's Always Sunny in Philadelphia (2010–2011), Portlandia (2011–2014), and The Last Man on Earth (2015–2018).
He had leading film roles in the comedies Horrible Bosses (2011) and its 2014 sequel, Horrible Bosses 2 (2014), and We're the Millers (2013), as well as the acclaimed independent films Drinking Buddies (2013), Sleeping with Other People (2015), and Colossal (2016); and supporting roles in Alexander Payne's Downsizing (2017) and Olivia Wilde's Booksmart (2019). He has also provided voice-work for Epic (2013), The Angry Birds Movie (2016), its 2019 sequel, and Next Gen (2018).